Bupropion (Generic Wellbutrin)
Below is a quick price comparison for Bupropion tablets. All prices include shipping and consultation fees. There are no more hidden costs for you.
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| Quantity | Product | Pharmacy | Price | Deliv. | Buy |
| 30 | Bupropion 100 mg | PillStore | $111 |  | Buy |
| 60 | Bupropion 100 mg | PillStore | $131 | | Buy |
| 90 | Bupropion 100 mg | PillStore | $151 | | Buy |
| 30 | Bupropion 75 mg | PillStore | $101 | | Buy |
| 60 | Bupropion 75 mg | PillStore | $121 | | Buy |
| 90 | Bupropion 75 mg | PillStore | $141 | | Buy |
Bupropion (bupropion hydrochloride) - Generic Wellbutrin, an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines. It has a bitter taste and produces the sensation of local anesthesia on the oral mucosa.
Pharmacology
The neurochemical mechanism of the antidepressant effect of bupropion is not known. Bupropion does not inhibit monoamine oxidase. Compared to classical tricyclic antidepressants, it is a weak blocker of the neuronal uptake of serotonin and norepinephrine; it also inhibits the neuronal re-uptake of dopamine to some extent.
In humans, following oral administration of bupropion, peak plasma bupropion concentrations are usually achieved within 2 hours.
Indications and Usage
Bupropion (Wellbutrin) is indicated for the treatment of depression. A physician considering bupropion for the management of a patient's first episodes of depression should be aware that the drug may cause generalized seizures with an approximate incidence of 0.4% (4/1000). This incidence of seizures may exceed that of other marketed antidepressants by as much as fourfold. This relative risk is only an approximate estimate because no direct comparative studies have been conducted.
Effectiveness of bupropion in long-term use, that is, for more than 6 weeks, has not been systematically evaluated in controlled trials. Therefore, the physician who elects to use bupropion for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient.
Contraindications
Bupropion is contraindicated in patients with a seizure disorder. Bupropion is also contraindicated in patients with a current or prior diagnosis of bulimia or anorexia nervosa because of a higher incidence of seizures noted in such patients treated with bupropion. The concurrent administration of bupropion and a monoamine oxidase (MAO) inhibitor is contraindicated. At least 14 days should elapse between discontinuation of an MAO inhibitor and initiation of treatment with bupropion. Bupropion is contraindicated in patients who have shown an allergic response to it.
